I. Single-cell proteogenomics of the human cell cycle
The cell cycle is driven by precise regulation of proteins in time and space, which also causes cell-to-cell heterogeneity. To study this heterogeneity in co...
Research Highlights
II. Proteogenomic database creation
Each of us has thousands of variations in our genomes, alternative splicing in our transcriptomes, and post-translational modifications (PTMs) adorning our p...
III. Proteoform family identification, quantification, and visualization
Proteoform families I created software named Proteoform Suite, along with other members of Prof. Smith’s research group, that automated the identification, q...
IV. ProForma: a standardized notation for writing proteoform sequences
ProForma: a standardized notation for writing proteoform sequences While the notation for writing protein sequences is defined by IUPAC, there is no such def...
V. Discovered lncRNAs that differentiate aggressive and indolent prostate cancers
Distinguishing between aggressive and indolent prostate cancers is currently performed by invasive biopsies and traditional and imprecise immunohistopatholog...
VI. Validated new techniques for hybridization capture analysis of RNA- and DNA-binding proteins
Revealing protein interactomes for DNA loci and RNAs Ensembles of proteins bind RNA and DNA and have typically been profiled by immunoprecipitation (IP) meth...