Area 1: Revealing proteoform families underlying cellular processes and diseases.
Proteins are involved in nearly every biological process, and there is widespread variation in protein expression between cells and within cellular substr...
Future Research
Area 2: Building a framework for quantifying proteoform family dynamics.
Proteoform families are defined by dynamic modifications with important functional consequences; this proteoform flux is thus worth investigating. However, ...
Area 3: Discerning proteoform function with spatial proteomics.
Spatial variations in protein expression within cells are widespread and can allow proteins to have multiple functions. We will garner experimental evidenc...